Missouri Travel Directory

Pony Express Lake Conservation Area in St. Joseph. Photo by Lisa D. Smith

The Show-Me State's Historic Corridor

The Jefferson Highway through Missouri follows a north-south alignment that was once critical to connecting the nation's heartland. The route primarily follows the U.S. 69/71 corridor through the western half of the state, serving historic railroad towns like Cameron and St. Joseph (where the highway association had its headquarters). From the majestic Missouri State Capitol in Jefferson City to the birthplace of President Harry S. Truman, the Missouri route is filled with Civil War history, frontier legends, and key intersections with other legendary auto trails, including the Pikes Peak Ocean to Ocean Highway.

Missouri Travel Directory Map

A work in progress, this Missouri Travel Directory Map displays the Jefferson Highway corridor. Use the interactive pins to locate our featured listings, including Visitor Bureaus, historic lodgings, restaurants, attractions and activities, and other businesses that welcome travelers along the route.   

Attractions & Experiences

Discover the best natural, historical, and unique experiences to add to your Jefferson Highway journey through Missouri.

Cameron Depot Museum

Located at the historic crossing of the Jefferson Highway (Chestnut Street) and the Pikes Peak Ocean to Ocean Highway, this museum features exhibits on the town's railroad and auto trail history.

 

St. Joseph Auto Trail Junction

St. Joseph was the national headquarters for the Jefferson Highway Association for a time and marks the crucial crossing of the Jefferson Highway and the Pikes Peak Ocean to Ocean Highway.

  • Address: Vicinity of 5th and Jules Streets / 10th and Francis, in downtown St. Joseph MO

Lodging Destinations

Find the perfect place to stay and plan your Missouri Jefferson Highway adventure with these lodging destinations.

Boots Court Motel & Visitor Center

The beautifully restored 1939 Streamline Moderne motel, designated a Jefferson Highway Tourist Center, is located at the "Crossroads of America" (JH & Route 66). It features 13 restored rooms, a gift shop, and guided tours. Click here for more...

  • Address: 107 S. Garrison Avenue (Route 66 and the Jefferson HWY), Carthage, MO 64836

  • Phone: +1 (417) 310-2989

  • Website: https://bootscourt66.com/ 

Shopping

Browse local boutiques, antique stores, art galleries, and specialty gift shops for unique finds and souvenirs along the route in Missouri.

Dandelion Creek Co.

Find handmade goat milk soaps from their own goats, honored as Rural Missouri’s Best Product 2025. A unique, local find right on Main Street.